MBD3 antibody (C-Term) (Fluoro488)

Catalog No. ABIN8009586

The Rabbit Polyclonal anti-MBD3 antibody is suitable to detect MBD3 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for MBD3 antibody (C-Term) (Fluoro488) (ABIN8009586)

Target: MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBD3 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-MBD3 Antibody (Fluoro488)

Binding Specificity: C-Term

Purpose: Anti-MBD3 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human MBD3 shares 100% amino acid (aa) sequence identity with mouse MBD3.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MBD3. Human MBD3 shares 100% amino acid (aa) sequence identity with mouse MBD3.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MBD3

Target: MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

Alternative Name: MBD3

Background:

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.

Gene Full Name: methyl-CpG binding domain protein 3

Gene ID: 53615

UniProt: O95983

Pathways: Chromatin Binding