MAP2K5 antibody (AA 401-445) (PE)

Catalog No. ABIN8011199

This Rabbit Polyclonal antibody specifically detects MAP2K5 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MAP2K5 antibody (AA 401-445) (PE) (ABIN8011199)

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP2K5 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-MAP2K5 Antibody (PE)

Binding Specificity: AA 401-445

Purpose: Anti-MEK5/MAP2K5 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MEK5/MAP2K5 recombinant protein (Position: R401-Q445).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Alternative Name: MAP2K5

Background:

Background: Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

Gene Full Name: mitogen-activated protein kinase kinase 5

Gene ID: 5607

UniProt: Q13163

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway