MAP2K6 antibody (AA 280-334) (APC)

Catalog No. ABIN8011209

The Rabbit Polyclonal anti-MAP2K6 antibody is suitable to detect MAP2K6 in samples from Human and Rat. It has been validated for FACS.

Quick Overview for MAP2K6 antibody (AA 280-334) (APC) (ABIN8011209)

Target: MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP2K6 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-MAP2K6 Antibody (APC)

Binding Specificity: AA 280-334

Purpose: Anti-MEK6/MAP2K6 Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: coli-derived human MEK6 recombinant protein (Position: A280-D334). Human MEK6 shares 92.7% amino acid (aa) sequence identity with mouse MEK6.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human MEK6 recombinant protein (Position: A280-D334). Human MEK6 shares 92.7% amino acid (aa) sequence identity with mouse MEK6.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MAP2K6

Target: MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))

Alternative Name: MAP2K6

Background:

Background: MAP2K6 (Mitogen-activated protein kinase kinase 6), also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene. It is located on chromosome 17. MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediatedsignal transduction pathway, this gene is involved in many cellular processes such as stress-induced cell cycle arrest, transcription activation and apoptosis.

Gene Full Name: mitogen-activated protein kinase kinase 6

Gene ID: 5608

UniProt: P52564

Pathways: MAPK Signaling, TLR Signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades