Menin antibody (AA 301-615) (Fluoro488)

Catalog No. ABIN8012040

The Rabbit Polyclonal anti-Menin antibody is suitable to detect Menin in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for Menin antibody (AA 301-615) (Fluoro488) (ABIN8012040)

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Menin antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-Menin Antibody (Fluoro488)

Binding Specificity: AA 301-615

Purpose: Anti-Menin/MEN1 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Menin shares 93%,94% amino acid (aa) sequence identity with mouse,rat Menin,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Menin recombinant protein (Position: P301-L615). Human Menin shares 93% and 94% amino acid (aa) sequence identity with mouse and rat Menin, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Alternative Name: MEN1

Background:

Background: The MEN1 gene encodes menin, a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling. It is mapped to 11q13.1. MEN1 is considered to act as a tumor suppressor gene. It has been found that that MEN1 inactivation by antisense RNA antagonizes transforming growth factor-beta-mediated cell growth inhibition. Overexpression of MEN1 in an inducible cell culture system downregulated the proximal promoter. In vitro studies have shown that MEN1 is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. What's more, MEN1 was essential to maintain MLL-associated myeloid transformation.

Gene Full Name: menin 1

Gene ID: 4221

UniProt: O00255

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity