Neuregulin 1 antibody (AA 2-241) (Fluoro594)

Catalog No. ABIN8014530

The Rabbit Polyclonal anti-Neuregulin 1 antibody is suitable to detect Neuregulin 1 in samples from Human. It has been validated for FACS.

Quick Overview for Neuregulin 1 antibody (AA 2-241) (Fluoro594) (ABIN8014530)

Target: Neuregulin 1 (NRG1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 1 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-Neuregulin 1 Antibody (Fluoro594)

Binding Specificity: AA 2-241

Purpose: Anti-NRG1 Antibody Fluoro594 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human NRG1 shares 94% amino acid (aa) sequence identity with rat NRG1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NRG1 recombinant protein (Position: S2-K241). Human NRG1 shares 94% amino acid (aa) sequence identity with rat NRG1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: NRG1

Background:

Background: The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Gene Full Name: neuregulin 1

Sequence Similarities: Belongs to the neuregulin family.

Gene ID: 3084

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation