NLRP6 antibody (AA 14-887) (APC)

Catalog No. ABIN8015919

The Rabbit Polyclonal anti-NLRP6 antibody is suitable to detect NLRP6 in samples from Human. It has been validated for FACS.

Quick Overview for NLRP6 antibody (AA 14-887) (APC) (ABIN8015919)

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP6 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-NLRP6 Antibody (APC)

Binding Specificity: AA 14-887

Purpose: Anti-NLRP6 Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human NLRP6 shares 71.7%,72.9% amino acid (aa) sequence identity with mouse,rat NLRP6,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NLRP6 recombinant protein (Position: R14-E887). Human NLRP6 shares 71.7% and 72.9% amino acid (aa) sequence identity with mouse and rat NLRP6, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NLRP6

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Alternative Name: NLRP6

Background:

Background: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: NLR family pyrin domain containing 6

Gene ID: 171389

UniProt: P59044

Pathways: Inflammasome