NLRP6 antibody (AA 14-887)

Catalog No. ABIN8015922

The Rabbit Polyclonal anti-NLRP6 antibody is suitable to detect NLRP6 in samples from Human. It has been validated for ELISA, WB and FACS.

Quick Overview for NLRP6 antibody (AA 14-887) (ABIN8015922)

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP6 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-NLRP6 Antibody

Binding Specificity: AA 14-887

Purpose: Anti-NLRP6 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human NLRP6 shares 71.7%,72.9% amino acid (aa) sequence identity with mouse,rat NLRP6,respectively.

Characteristics: Anti-NLRP6 Antibody. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NLRP6 recombinant protein (Position: R14-E887). Human NLRP6 shares 71.7% and 72.9% amino acid (aa) sequence identity with mouse and rat NLRP6, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for NLRP6

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Alternative Name: NLRP6

Background:

Background: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: NLR family pyrin domain containing 6

Molecular Weight: 105 kDa

Gene ID: 171389

UniProt: P59044

Pathways: Inflammasome