ORC2 antibody (AA 130-493) (Fluoro550)

Catalog No. ABIN8018372

This Rabbit Polyclonal antibody specifically detects ORC2 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ORC2 antibody (AA 130-493) (Fluoro550) (ABIN8018372)

Target: ORC2 (Origin Recognition Complex Subunit 2 (ORC2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORC2 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-ORC2 Antibody (Fluoro550)

Binding Specificity: AA 130-493

Purpose: Anti-ORC2 Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human ORC2 shares 80.2%,79.4% amino acid (aa) sequence identity with mouse,rat ORC2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ORC2 recombinant protein (Position: E130-R493). Human ORC2 shares 80.2% and 79.4% amino acid (aa) sequence identity with mouse and rat ORC2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ORC2

Target: ORC2 (Origin Recognition Complex Subunit 2 (ORC2))

Alternative Name: ORC2

Background:

Background: Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans. The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.

Gene Full Name: origin recognition complex subunit 2

Gene ID: 4999

UniProt: Q13416