PHGDH antibody (AA 15-533) (Fluoro594)

Catalog No. ABIN8021695

The Fluoro594-conjugated Rabbit Polyclonal anti-PHGDH antibody (ABIN8021695) specifically detects PHGDH in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PHGDH antibody (AA 15-533) (Fluoro594) (ABIN8021695)

Target: PHGDH (phosphoglycerate Dehydrogenase (PHGDH))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHGDH antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-PHGDH Antibody (Fluoro594)

Binding Specificity: AA 15-533

Purpose: Anti-PHGDH Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human PHGDH shares 94.4%,94.2% amino acid (aa) sequence identity with mouse,rat PHGDH,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PHGDH recombinant protein (Position: L15-F533). Human PHGDH shares 94.4% and 94.2% amino acid (aa) sequence identity with mouse and rat PHGDH, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PHGDH

Target: PHGDH (phosphoglycerate Dehydrogenase (PHGDH))

Alternative Name: PHGDH

Background:

Background: This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

Gene Full Name: phosphoglycerate dehydrogenase

Gene ID: 26227

UniProt: O43175

Pathways: Metabolism of Steroid Hormones and Vitamin D, Warburg Effect