PLCD1 antibody (AA 14-549) (Fluoro550)

Catalog No. ABIN8022161

This Rabbit Polyclonal antibody specifically detects PLCD1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PLCD1 antibody (AA 14-549) (Fluoro550) (ABIN8022161)

Target: PLCD1 (phospholipase C, delta 1 (PLCD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLCD1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-PLCD1 Antibody (Fluoro550)

Binding Specificity: AA 14-549

Purpose: Anti-PLCD1 Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human PLCD1 shares 92.2%,92.5% amino acid (aa) sequence identity with mouse,rat PLCD1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PLCD1 recombinant protein (Position: Q14-R549). Human PLCD1 shares 92.2% and 92.5% amino acid (aa) sequence identity with mouse and rat PLCD1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PLCD1

Target: PLCD1 (phospholipase C, delta 1 (PLCD1))

Alternative Name: PLCD1

Background:

Background: This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Full Name: phospholipase C delta 1

Gene ID: 5333

UniProt: P51178

Pathways: WNT Signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process