PIM1 antibody (C-Term) (FITC)

Catalog No. ABIN8022573

The Rabbit Polyclonal anti-PIM1 antibody is suitable to detect PIM1 in samples from Human. It has been validated for FACS.

Quick Overview for PIM1 antibody (C-Term) (FITC) (ABIN8022573)

Target: PIM1 (Pim-1 Oncogene (PIM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIM1 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-PIM1 Antibody (FITC)

Binding Specificity: C-Term

Purpose: Anti-PIM1 Antibody FITC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse sequence by seven amino acids,from the related rat sequence by two amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PIM1, different from the related mouse sequence by seven amino acids and from the related rat sequence by two amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PIM1

Target: PIM1 (Pim-1 Oncogene (PIM1))

Alternative Name: PIM1

Background:

Background: Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene. It is mapped to 6p21.2. Primarily expressed in spleen, thymus, bone marrow, prostate, oral epithelial, hippocampus and fetal liver cells, Pim-1 has also been found to be highly expressed in cell cultures isolated from human tumors. Pim-1 is mainly involved in cell cycle progression, apoptosis and transcriptional activation, as well as more general signal transduction pathways. It has been found a physiologic role of the PIM1 oncogene during hematopoietic development and a deregulation of the gene in various leukemias. PIM1 also has a role in cardioprotection downstream of AKT activation.

Gene Full Name: Pim-1 proto-oncogene, serine/threonine kinase

Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

Gene ID: 5292

UniProt: P11309

Pathways: Glycosaminoglycan Metabolic Process