Poliovirus Receptor antibody (AA 24-345) (Fluoro647)

Catalog No. ABIN8023632

The Rabbit Polyclonal anti-Poliovirus Receptor antibody is suitable to detect Poliovirus Receptor in samples from Mouse and Rat. It has been validated for FACS.

Quick Overview for Poliovirus Receptor antibody (AA 24-345) (Fluoro647) (ABIN8023632)

Target: Poliovirus Receptor (PVR)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Poliovirus Receptor antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Poliovirus Receptor Antibody (Fluoro647)

Binding Specificity: AA 24-345

Purpose: Anti-Poliovirus Receptor/PVR Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Poliovirus Receptor/PVR recombinant protein (Position: R24-R345).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Poliovirus Receptor

Target: Poliovirus Receptor (PVR)

Alternative Name: PVR

Background:

Background: CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that in humans is encoded by the PVR gene. The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: PVR cell adhesion molecule

Gene ID: 52118

UniProt: Q91WP1

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome