PARL antibody (Middle Region) (Cy3)

Catalog No. ABIN8025208

The Cy3-conjugated Rabbit Polyclonal anti-PARL antibody (ABIN8025208) specifically detects PARL in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PARL antibody (Middle Region) (Cy3) (ABIN8025208)

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARL antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-PARL Antibody (Cy3)

Binding Specificity: Middle Region

Purpose: Anti-PARL Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human PARL shares 98.8% amino acid (aa) sequence identity with both mouse,rat PARL.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human PARL. Human PARL shares 98.8% amino acid (aa) sequence identity with both mouse and rat PARL.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PARL

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Alternative Name: PARL

Background:

Background: This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease.

Gene Full Name: presenilin associated rhomboid like

Gene ID: 55486

UniProt: Q9H300

Pathways: Autophagy