RAD51 Homolog B antibody (AA 22-384) (PE)

Catalog No. ABIN8030103

The Rabbit Polyclonal anti-RAD51 Homolog B antibody is suitable to detect RAD51 Homolog B in samples from Human. It has been validated for FACS.

Quick Overview for RAD51 Homolog B antibody (AA 22-384) (PE) (ABIN8030103)

Target: RAD51 Homolog B (Rad51B)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD51 Homolog B antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-RAD51 Homolog B Antibody (PE)

Binding Specificity: AA 22-384

Purpose: Anti-RAD51L1/RAD51B Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human RAD51L1,RAD51B shares 85.8% amino acid (aa) sequence identity with mouse RAD51L1,RAD51B.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RAD51L1/RAD51B recombinant protein (Position: H22-F384). Human RAD51L1/RAD51B shares 85.8% amino acid (aa) sequence identity with mouse RAD51L1/RAD51B.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for RAD51 Homolog B

Target: RAD51 Homolog B (Rad51B)

Alternative Name: RAD51B

Background:

Background: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.

Gene Full Name: RAD51 paralog B

Gene ID: 5890

UniProt: O15315

Pathways: DNA Damage Repair