RRN3 antibody (AA 184-651) (Biotin)

Catalog No. ABIN8033997

The Rabbit Polyclonal anti-RRN3 antibody is suitable to detect RRN3 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for RRN3 antibody (AA 184-651) (Biotin) (ABIN8033997)

Target: RRN3 (RRN3 RNA Polymerase I Transcription Factor (RRN3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRN3 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RRN3 Antibody (Biotin)

Binding Specificity: AA 184-651

Purpose: Anti-RRN3 Antibody Biotin Conjugated

Predicted Reactivity: Human RRN3 shares 87.4% amino acid (aa) sequence identity with mouse RRN3.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RRN3 recombinant protein (Position: D184-L651). Human RRN3 shares 87.4% amino acid (aa) sequence identity with mouse RRN3.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RRN3

Target: RRN3 (RRN3 RNA Polymerase I Transcription Factor (RRN3))

Alternative Name: RRN3

Background:

Background: RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1.

Gene Full Name: RNA polymerase I transcription factor RRN3

Gene ID: 54700

UniProt: Q9NYV6

Pathways: Negative Regulation of intrinsic apoptotic Signaling