SLFN11 antibody (AA 114-794) (Fluoro550)

Catalog No. ABIN8034738

The Rabbit Polyclonal anti-SLFN11 antibody is suitable to detect SLFN11 in samples from Human. It has been validated for FACS.

Quick Overview for SLFN11 antibody (AA 114-794) (Fluoro550) (ABIN8034738)

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLFN11 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-SLFN11 Antibody (Fluoro550)

Binding Specificity: AA 114-794

Purpose: Anti-SLFN11 Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SLFN11 recombinant protein (Position: P114-D794).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SLFN11

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Alternative Name: SLFN11

Background:

Background: Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.

Gene Full Name: schlafen family member 11

Gene ID: 91607

UniProt: Q7Z7L1