Septin 5 antibody (C-Term) (PE)

Catalog No. ABIN8035723

The PE-conjugated Rabbit Polyclonal anti-Septin 5 antibody (ABIN8035723) specifically detects Septin 5 in FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for Septin 5 antibody (C-Term) (PE) (ABIN8035723)

Target: Septin 5 (SEPT5)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Septin 5 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Septin 5 Antibody (PE)

Binding Specificity: C-Term

Purpose: Anti-SEPT5/SEPTIN5 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: identical to the related mouse,rat sequences.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SEPT5/SEPTIN5, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Septin 5

Target: Septin 5 (SEPT5)

Alternative Name: SEPTIN5

Background:

Background: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB, platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Gene Full Name: septin 5

Gene ID: 5413

UniProt: Q99719

Pathways: Synaptic Vesicle Exocytosis