SPON2 antibody (AA 53-331) (Fluoro488)

Catalog No. ABIN8041975

The Fluoro488-conjugated Rabbit Polyclonal anti-SPON2 antibody (ABIN8041975) specifically detects SPON2 in FACS. The antibody is reactive with Human samples.

Quick Overview for SPON2 antibody (AA 53-331) (Fluoro488) (ABIN8041975)

Target: SPON2 (Spondin 2 (SPON2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPON2 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-SPON2 Antibody (Fluoro488)

Binding Specificity: AA 53-331

Purpose: Anti-SPON2 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SPON2 recombinant protein (Position: Q53-V331).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SPON2

Target: SPON2 (Spondin 2 (SPON2))

Alternative Name: SPON2

Background:

Background: Spondin 2, also known as mindin, is a protein that in humans is encoded by the SPON2 gene. SPON2 (spondin 2, mindin) is an extracellular matrix protein belonging to the mindin/F-spondin family. The protein has two amino terminal follistatin-like (FS) domains and a carboxy terminal thrombospondin type 1 repeat (TSR) domain. The FS domains mediate interactions between SPON2 and integrins, whereas the TSR domain contributes to the role of SPON2 as a pathogen pattern recognition molecule. In that capacity, SPON2 plays an important role in initiation of the innate immune response. It functions as a pattern recognition molecule within the extracellular matrix, where it binds to microbial pathogens and presents them to immune cells. Interactions between SPON2 and integrins are also critical for inflammatory cell recruitment and T cell priming. In addition to its role in innate immunity, SPON2 has also been shown to play a role in hippocampal neuronal outgrowth, cancer metastasis, and diabetic nephropathy.

Gene Full Name: spondin 2

Gene ID: 10417

UniProt: Q9BUD6