SSRP1 antibody (AA 2-381) (APC)

Catalog No. ABIN8043233

This Rabbit Polyclonal antibody specifically detects SSRP1 in FACS. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for SSRP1 antibody (AA 2-381) (APC) (ABIN8043233)

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSRP1 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-SSRP1 Antibody (APC)

Binding Specificity: AA 2-381

Purpose: Anti-SSRP1 Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SSRP1 recombinant protein (Position: A2-R381).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SSRP1

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Alternative Name: SSRP1

Background:

Background: FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene. The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.

Gene Full Name: structure specific recognition protein 1

Gene ID: 6749

UniProt: Q08945

Pathways: Chromatin Binding