SOCS4 antibody (AA 291-440) (Fluoro647)

Catalog No. ABIN8043776

This Rabbit Polyclonal antibody specifically detects SOCS4 in FACS. It exhibits reactivity toward Human.

Quick Overview for SOCS4 antibody (AA 291-440) (Fluoro647) (ABIN8043776)

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS4 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-SOCS4 Antibody (Fluoro647)

Binding Specificity: AA 291-440

Purpose: Anti-SOCS4 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human SOCS4 shares 98% amino acid (aa) sequence identity with mouse SOCS4.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SOCS4 recombinant protein (Position: M291-C440). Human SOCS4 shares 98% amino acid (aa) sequence identity with mouse SOCS4.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SOCS4

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Alternative Name: SOCS4

Background:

Background: SOCS4, also known as Suppressor of cytokine signaling 4, is mapped to 14q22.1. The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene Full Name: suppressor of cytokine signaling 4

Sequence Similarities: Contains 1 SH2 domain.

Gene ID: 122809

UniProt: Q8WXH5

Pathways: JAK-STAT Signaling, EGFR Signaling Pathway