SYNGAP1 antibody (AA 3-1175) (Cy3)

Catalog No. ABIN8044253

This Rabbit Polyclonal antibody specifically detects SYNGAP1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SYNGAP1 antibody (AA 3-1175) (Cy3) (ABIN8044253)

Target: SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNGAP1 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-SYNGAP1 Antibody (Cy3)

Binding Specificity: AA 3-1175

Purpose: Anti-SYNGAP1 Antibody Cy3 Conjugated

Predicted Reactivity: Human SYNGAP1 shares 99%,99.1% amino acid (aa) sequence identity with mouse,rat SYNGAP1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SYNGAP1 recombinant protein (Position: R3-R1175). Human SYNGAP1 shares 99% and 99.1% amino acid (aa) sequence identity with mouse and rat SYNGAP1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SYNGAP1

Target: SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))

Alternative Name: SYNGAP1

Background:

Background: Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants.

Gene Full Name: synaptic Ras GTPase activating protein 1

Gene ID: 8831

UniProt: Q96PV0

Pathways: Regulation of long-term Neuronal Synaptic Plasticity