TYMS antibody (AA 1-313) (APC)

Catalog No. ABIN8046529

The APC-conjugated Rabbit Polyclonal anti-TYMS antibody (ABIN8046529) specifically detects TYMS in FACS. The antibody is reactive with Human, Rat and Monkey samples.

Quick Overview for TYMS antibody (AA 1-313) (APC) (ABIN8046529)

Target: TYMS (Thymidylate Synthetase (TYMS))

Reactivity: Human, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYMS antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-TYMS Antibody (APC)

Binding Specificity: AA 1-313

Purpose: Anti-Thymidylate Synthase/TYMS Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Thymidylate Synthase/TYMS recombinant protein (Position: M1-V313).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Alternative Name: TYMS

Background:

Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.

Gene Full Name: thymidylate synthetase

Gene ID: 7298

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases