TIA1 antibody (N-Term) (PE)

Catalog No. ABIN8046684

The Rabbit Polyclonal anti-TIA1 antibody is suitable to detect TIA1 in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for TIA1 antibody (N-Term) (PE) (ABIN8046684)

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIA1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-TIA1 Antibody (PE)

Binding Specificity: N-Term

Purpose: Anti-Nucleolysin TIA-1 isoform p40 TIA1 Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related mouse sequence.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human TIA1, identical to the related mouse sequence.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for TIA1

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Alternative Name: TIA1

Background:

Background: TIA1, also called WDM, encodes an RNA-binding protein involved in splicing regulation and translational repression. The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. By in situ hybridization, this gene is mapped to chromosome 2p13.3. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is though to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing.

Gene Full Name: TIA1 cytotoxic granule associated RNA binding protein

Sequence Similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Gene ID: 7072

UniProt: P31483