TLR10 antibody (N-Term) (Biotin)

Catalog No. ABIN8047303

The Biotin-conjugated Rabbit Polyclonal anti-TLR10 antibody (ABIN8047303) specifically detects TLR10 in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for TLR10 antibody (N-Term) (Biotin) (ABIN8047303)

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR10 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-TLR10 Antibody (Biotin)

Binding Specificity: N-Term

Purpose: Anti-Toll-like receptor 10 TLR10 Antibody Biotin Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human TLR10.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TLR10

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Alternative Name: TLR10

Background:

Background: TLR10 (Toll-like receptor 10), is a protein that in humans is encoded by the TLR10 gene. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. By genomic sequence analysis, Hasan et al. (2005) determined that the TLR10 gene is clustered with TLR1 and TLR6 on chromosome 4p14. By coimmunoprecipitation analysis, Hasan et al. (2005) found that TLR10 associated with itself and with TLR1 and TLR2, but not with MD2. Signaling studies showed that TLR10 required MYD88, but not TIRAP, TRAM (TICAM2), or TRIF (TICAM1), to activate immune system promoters. Pro674 within the TLR10 TIR domain was required to activate all promoter examined.

Gene Full Name: toll like receptor 10

Sequence Similarities: Belongs to the Toll-like receptor family.

Gene ID: 81793

UniProt: Q9BXR5

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades