TIGAR antibody (AA 1-270) (HRP)

Catalog No. ABIN8047628

This Rabbit Polyclonal antibody specifically detects TIGAR in WB, ELISA and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TIGAR antibody (AA 1-270) (HRP) (ABIN8047628)

Target: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIGAR antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TIGAR Antibody (HRP)

Binding Specificity: AA 1-270

Purpose: Anti-TIGAR Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human TIGAR shares 72.8% amino acid (aa) sequence identity with mouse TIGAR.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TIGAR recombinant protein (Position: M1-R270). Human TIGAR shares 72.8% amino acid (aa) sequence identity with mouse TIGAR.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TIGAR

Target: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Alternative Name: TIGAR

Background:

Background: This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Gene Full Name: TP53 induced glycolysis regulatory phosphatase

Gene ID: 57103

UniProt: Q9NQ88

Pathways: Warburg Effect