ube3a antibody (AA 1-860) (APC)

Catalog No. ABIN8052115

The APC-conjugated Mouse Monoclonal anti-ube3a antibody (Clone 8I3) (ABIN8052115) specifically detects ube3a in FACS. The antibody is reactive with Human and Monkey samples.

Quick Overview for ube3a antibody (AA 1-860) (APC) (ABIN8052115)

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Reactivity: Human, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This ube3a antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: 8I3

Product Details anti-ube3a Antibody (APC)

Binding Specificity: AA 1-860

Purpose: Anti-UBE3A Antibody (monoclonal, 8I3) APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human UBE3A recombinant protein (Position: M1-E860).

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ube3a

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Alternative Name: UBE3A

Background:

Background: Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. It is mapped to 15q11.2. This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Gene Full Name: ubiquitin protein ligase E3A

Gene ID: 7337

UniProt: Q05086

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway