UNG antibody (AA 96-313) (Fluoro550)

Catalog No. ABIN8052898

The Fluoro550-conjugated Rabbit Polyclonal anti-UNG antibody (ABIN8052898) specifically detects UNG in FACS. The antibody is reactive with Human, Mouse, Rat and Monkey samples.

Quick Overview for UNG antibody (AA 96-313) (Fluoro550) (ABIN8052898)

Target: UNG (Uracil-DNA Glycosylase (UNG))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNG antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-UNG Antibody (Fluoro550)

Binding Specificity: AA 96-313

Purpose: Anti-UNG Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human UNG recombinant protein (Position: E96-L313).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Alternative Name: UNG

Background:

Background: Uracil-DNA glycosylase, also known as UNG or UDG, is a human gene though orthologs exist ubiquitously among prokaryotes and eukaryotes and even in some DNA viruses. The first uracil DNA-glycosylase was isolated from Escherichia coli. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene, which has been confused with this gene, in the literature and some databases.

Gene Full Name: uracil DNA glycosylase

Gene ID: 7374

UniProt: P13051

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response