WHSC2 antibody (AA 38-482) (Fluoro550)

Catalog No. ABIN8054483

This Rabbit Polyclonal antibody specifically detects WHSC2 in FACS. It exhibits reactivity toward Human.

Quick Overview for WHSC2 antibody (AA 38-482) (Fluoro550) (ABIN8054483)

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WHSC2 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-WHSC2 Antibody (Fluoro550)

Binding Specificity: AA 38-482

Purpose: Anti-NELFA Antibody Fluoro550 Conjugated

Predicted Reactivity: Human NELFA shares 94.6% amino acid (aa) sequence identity with mouse NELFA.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NELFA recombinant protein (Position: I38-L482). Human NELFA shares 94.6% amino acid (aa) sequence identity with mouse NELFA.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for WHSC2

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Alternative Name: NELFA

Background:

Background: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Gene Full Name: negative elongation factor complex member A

Gene ID: 7469

UniProt: Q9H3P2

Pathways: Chromatin Binding