XPC antibody (AA 146-838) (HRP)

Catalog No. ABIN8054817

The Rabbit Polyclonal anti-XPC antibody is suitable to detect XPC in samples from Human, Rat and Mouse. It has been validated for WB, ELISA and IHC.

Quick Overview for XPC antibody (AA 146-838) (HRP) (ABIN8054817)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPC antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-XPC Antibody (HRP)

Binding Specificity: AA 146-838

Purpose: Anti-XPC Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human XPC recombinant protein (Position: D146-E838).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Alternative Name: XPC

Background:

Background: Xeroderma pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Gene Full Name: XPC complex subunit, DNA damage recognition and repair factor

Gene ID: 7508

UniProt: Q01831

Pathways: p53 Signaling, DNA Damage Repair