XPC antibody (AA 146-838)

Catalog No. ABIN8054821

The Rabbit Polyclonal anti-XPC antibody (ABIN8054821) specifically detects XPC in WB, ELISA, FACS, ICC and IF. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for XPC antibody (AA 146-838) (ABIN8054821)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Grade: Carrier-free

Product Details anti-XPC Antibody

Binding Specificity: AA 146-838

Purpose: Anti-XPC Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-XPC Antibody. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human XPC recombinant protein (Position: D146-E838).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Alternative Name: XPC

Background:

Background: Xeroderma pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Gene Full Name: XPC complex subunit, DNA damage recognition and repair factor

Molecular Weight: 106 kDa

Gene ID: 7508

UniProt: Q01831

Pathways: p53 Signaling, DNA Damage Repair