Recombinant CKB antibody (full length)

Catalog No. ABIN8093100

The Rabbit Monoclonal anti-CKB antibody (Clone CKBB-8295R) (ABIN8093100) specifically detects CKB in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant CKB antibody (full length) (ABIN8093100)

Target: CKB (Creatine Kinase, Brain (CKB))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CKB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: CKBB-8295R

Product Details anti-CKB Antibody

Binding Specificity: full length

Purpose: CKB Antibody / Creatine kinase B

Immunogen: Recombinant full-length human CKB protein was used as the immunogen for the CKB/Creatine kinase B-type antibody.

Isotype: IgG, kappa

Application Details

Application Notes: 1. Optimal dilution of the CKB/Creatine kinase B-type antibody should be determined by the researcher.

2. This CKB/Creatine kinase B-type antibody is recombinantly produced by expression in human HEK293 cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: CKB/Creatine kinase B-type antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for CKB

Target: CKB (Creatine Kinase, Brain (CKB))

Alternative Name: CKB

Background: CKB antibody targets Creatine kinase B-type, a cytosolic enzyme encoded by the CKB gene that catalyzes the reversible transfer of a phosphate group between ATP and creatine, forming phosphocreatine and ADP. Creatine kinase B-type plays a central role in cellular energy homeostasis by buffering and rapidly regenerating ATP in cells with high and fluctuating energy demands. This enzyme represents the brain-type creatine kinase isoform and is widely expressed in neuronal tissues, glial cells, and other cell types with active energy metabolism. CKB antibody is therefore commonly applied in research focused on energy transfer systems, phosphagen metabolism, and cellular bioenergetics.

Creatine kinase B-type exists primarily as a homodimer but can also form heterodimers with the muscle-type creatine kinase subunit, giving rise to the CK-MB isoenzyme. The protein belongs to the creatine kinase family and contains conserved catalytic domains required for creatine and nucleotide binding. In addition to strong expression in the nervous system, CKB has been reported in epithelial tissues, endocrine organs, and proliferative cell populations, supporting its broader role in cellular metabolism beyond the brain. Clone CKBB/8295R is designed to recognize Creatine kinase B-type for research use in studies examining cellular energy dynamics and creatine kinase system regulation.

Altered expression of Creatine kinase B-type has been associated with neurological injury, neurodegenerative disease, and metabolic stress conditions. Changes in CKB levels have also been investigated in cancer biology, where shifts in cellular energy metabolism are a hallmark feature of tumor progression. Because the creatine kinase system is closely linked to ATP availability, redox balance, and cell survival, CKB remains an important research target in studies of neuronal health, metabolic adaptation, and disease-associated bioenergetic remodeling. Clone CKBB/8295R provides a tool for examining Creatine kinase B-type expression and distribution in experimental systems relevant to cellular metabolism and energy-dependent biological processes.

This Creatine Kinase B Antibody is part of a broader < a href=../creatine-kinase-b-antibody-ckb>Creatine Kinase B antibody panel offered by NSJ Bioreagents.

UniProt: P12277