Recombinant GRIA2 antibody

Catalog No. ABIN8093209

This Rabbit Monoclonal antibody specifically detects GRIA2 in WB and IHC. It exhibits reactivity toward Human, Rat, Mouse and Pig.

Quick Overview for Recombinant GRIA2 antibody (ABIN8093209)

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat, Mouse, Pig

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GRIA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: ACIB-7

Product Details anti-GRIA2 Antibody

Purpose: GLUR2 Antibody / Glutamate Receptor 2 / GRIA2

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human Glutamate Receptor 2 protein was used as the immunogen for the Glutamate Receptor 2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Glutamate Receptor 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Glutamate Receptor 2 antibody at -20oC.

Target Details for GRIA2

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Alternative Name: GLUR2

Background: Glutamate Receptor 2 antibody targets Glutamate receptor 2 (GRIA2), also commonly referred to as GLUR2, a ligand-gated ion channel subunit belonging to the AMPA-type glutamate receptor family. GRIA2 is a transmembrane protein predominantly localized to the postsynaptic membrane of excitatory synapses, where it plays a central role in fast synaptic transmission in the central nervous system. AMPA receptors are tetrameric complexes assembled from GRIA1-4 subunits, and the presence of GRIA2 within these complexes critically influences channel properties, including ion permeability and synaptic signaling behavior.

Functionally, GRIA2 is essential for regulating calcium permeability of AMPA receptors. A key feature of GRIA2 is RNA editing at the Q/R site within the channel pore, which renders GRIA2-containing AMPA receptors impermeable to calcium ions. This property distinguishes GRIA2 from other AMPA receptor subunits and has profound effects on neuronal excitability, synaptic plasticity, and protection against excitotoxicity. Through this mechanism, GRIA2 helps maintain neuronal stability while allowing rapid glutamatergic signaling required for learning and memory. A Glutamate Receptor 2 antibody supports studies focused on excitatory neurotransmission and synaptic function.

GRIA2 is widely expressed throughout the brain, including the cortex, hippocampus, cerebellum, and other regions involved in sensory processing and cognition. Its expression is particularly enriched at excitatory synapses, where it contributes to synaptic strength and plasticity. Changes in GRIA2 expression, localization, or subunit composition can alter synaptic signaling dynamics, making GRIA2 an important marker for studies of synaptic remodeling, development, and activity-dependent regulation. Analysis of GRIA2 distribution provides insight into the molecular organization of excitatory synapses.

From a biological and disease-relevance perspective, GRIA2 has been extensively studied in the context of neurological and neurodegenerative disorders. Alterations in GRIA2 expression or RNA editing have been linked to conditions such as epilepsy, ischemic injury, amyotrophic lateral sclerosis, and neurodevelopmental disorders. Dysregulation of GRIA2-containing AMPA receptors can increase calcium influx and contribute to neuronal vulnerability. As a result, GRIA2 is frequently investigated in studies examining mechanisms of excitotoxicity, synaptic dysfunction, and disease-associated neural circuit alterations.

At the molecular level, GRIA2 is encoded by the GRIA2 gene and produces a protein with an apparent molecular weight of approximately 100 kDa, though electrophoretic mobility can vary due to glycosylation and receptor assembly state. The protein contains multiple transmembrane domains and large extracellular regions involved in ligand binding and receptor gating. GRIA2 function is regulated by trafficking, phosphorylation, and interaction with scaffolding proteins at the synapse. A Glutamate Receptor 2 antibody supports research applications focused on synaptic biology, glutamatergic signaling, and nervous system function, with NSJ Bioreagents providing reagents intended for research use.

UniProt: P42262

Pathways: PI3K-Akt Signaling