Recombinant SOX10 antibody (AA 115-269)

Catalog No. ABIN8093493

The Mouse Monoclonal anti-SOX10 antibody (Clone rSOX10-991) (ABIN8093493) specifically detects SOX10 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant SOX10 antibody (AA 115-269) (ABIN8093493)

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOX10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: RSOX10-991

Product Details anti-SOX10 Antibody

Binding Specificity: AA 115-269

Purpose: SOX10 Antibody / Transcription factor SOX10 (azide and preservative free)

Immunogen: Recombinant human SOX10 protein fragment (around amino acids 115-269) (exact sequence is proprietary) was used as the immunogen for the Transcription factor SOX10 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: 1. Optimal dilution of the Transcription factor SOX10 antibody should be determined by the researcher.

2. This Transcription factor SOX10 antibody is recombinantly produced by expression in CHO cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Transcription factor SOX10 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for SOX10

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Alternative Name: SOX10

Background: Transcription factor SOX10 Antibody recognizes SRY-box transcription factor 10, encoded by the SOX10 gene and belonging to the SOX family of high mobility group box DNA-binding proteins. SOX10 is a nuclear transcription factor characterized by a conserved HMG-box domain that enables sequence-specific DNA binding and modulation of gene expression programs essential for neural crest development. Transcription factor SOX10 Antibody detects this predominantly nuclear protein that regulates lineage specification and differentiation of neural crest-derived cell populations.

During embryogenesis, SOX10 plays a central role in neural crest cell survival, migration, and differentiation. It is required for development of melanocytes, Schwann cells, peripheral glia, and components of the enteric nervous system. In melanocyte biology, SOX10 functions upstream of MITF and regulates genes involved in pigment synthesis, melanocyte proliferation, and cellular maintenance. In peripheral nerve development, SOX10 coordinates Schwann cell maturation and myelination programs through interaction with signaling pathways such as Wnt, Notch, and neuregulin-mediated cascades.

In adult tissues, SOX10 expression remains largely restricted to melanocytes located within the basal layer of the epidermis and hair follicles and to Schwann cells associated with peripheral nerves. This lineage-specific distribution makes SOX10 antibody a valuable marker for identifying neural crest-derived cell types. The characteristic nuclear staining pattern reflects the transcriptional function of SOX10 within positive cells.

SOX10 has significant relevance in cancer research. Expression is frequently observed in melanoma, malignant peripheral nerve sheath tumors, and clear cell sarcoma, where nuclear localization supports identification of melanocytic or neural crest differentiation. SOX10 expression has also been reported in subsets of basal-like breast carcinoma and salivary gland neoplasms, reflecting shared developmental regulatory pathways. Altered SOX10 signaling has been associated with tumor progression and cellular plasticity in melanoma and related malignancies.

Transcription factor SOX10 Antibody / SOX10 (clone rSOX10/991) is a recombinant monoclonal antibody suitable for detecting SOX10 protein expression in research applications focused on neural crest biology, melanocyte differentiation, peripheral nerve studies, and tumor characterization.

UniProt: P56693

Pathways: Chromatin Binding