IL13 Receptor alpha 1 antibody (N-Term)

Catalog No. ABIN8103334

This Rabbit Polyclonal antibody specifically detects IL13 Receptor alpha 1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse, Pig, Sheep and Dog.

Quick Overview for IL13 Receptor alpha 1 antibody (N-Term) (ABIN8103334)

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse, Pig, Sheep, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL13 Receptor alpha 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL13 Receptor alpha 1 Antibody

Binding Specificity: N-Term

Purpose: IL13RA1 Antibody - N-terminal region

Sequence: YFSHFGDKQD KKIAPETRRS IEVPLNERIC LQVGSQCSTN ESEKPSILVE

Predicted Reactivity: Cow: 100%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human I13R1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63415-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL13 Receptor alpha 1

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Alternative Name: IL13RA1

Background:

Background Information: The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

Gene Name: interleukin 13 receptor subunit alpha 1

Alternative Symbols: NR4, CT19, CD213A1, IL-13Ra

Protein Name: interleukin-13 receptor subunit alpha-1

Molecular Weight: 46kDa

Gene ID: 3597

NCBI Accession: NP_001551

UniProt: P78552

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response