TICAM2 antibody (N-Term)

Catalog No. ABIN8113977

The Rabbit Polyclonal anti-TICAM2 antibody (ABIN8113977) specifically detects TICAM2 in WB. The antibody is reactive with Human samples.

Quick Overview for TICAM2 antibody (N-Term) (ABIN8113977)

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TICAM2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TICAM2 Antibody

Binding Specificity: N-Term

Purpose: TICAM2 Antibody - N-terminal region

Sequence: VDTSPGYHES DSKKSEDLSL CNVAEHSNTT EGPTGKQEGA QSVEEMFEEE

Predicted Reactivity: Human: 100%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TCAM2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64855-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TICAM2

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Alternative Name: TICAM2

Background:

Background Information: This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway.

Gene Name: TMED7-TICAM2 readthrough

Alternative Symbols: TIRP, TRAM, TICAM2, TIRAP3, MyD88-4, TICAM-2

Protein Name: TRAM adaptor with GOLD domain

Molecular Weight: 25kDa

Gene ID: 100302736

NCBI Accession: NP_067681

UniProt: Q86XR7

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades