Claudin 18 antibody (AA 150-261)

Catalog No. ABIN8120597

This Mouse Monoclonal antibody specifically detects Claudin 18 in IHC. It exhibits reactivity toward Human.

Quick Overview for Claudin 18 antibody (AA 150-261) (ABIN8120597)

Target: Claudin 18 (CLDN18)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Claudin 18 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1310

Product Details anti-Claudin 18 Antibody

Binding Specificity: AA 150-261

Purpose: Claudin 18 mouse mAb

Specificity: The antibody can specifically recognize both human Claudin 18. 1 and Claudin 18. 2 protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 150 - 261 of the human Claudin 18 protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for Claudin 18

Target: Claudin 18 (CLDN18)

Alternative Name: Claudin 18

Background:

Synonyms: Claudin 18, Claudin-18, CLD18_HUMAN, CLDN18, SFTA5, SFTPJ

Background: Claudin 18 is a 27 kDa membrane protein, belonging to the tight junction protein family. It is highly specifically expressed in gastric epithelial cells, and almost not expressed in other normal tissues. Studies have shown that the expression of gastric tissue increases after cancer, and the abnormal expression in pancreatic cancer, lung cancer, esophageal cancer and ovarian cancer promotes the metastasis of cancer cells. Therefore, antibody based drugs against Claudin 18 can significantly improve the survival rate of patients.

Gene Name: CLDN18

Protein Name: Claudin 18

Gene ID: 51208

UniProt: P56856

Pathways: Cell-Cell Junction Organization, Hepatitis C