Cortactin antibody (acLys235)

Catalog No. ABIN8120743

The Rabbit Polyclonal anti-Cortactin antibody (ABIN8120743) specifically detects Cortactin in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Cortactin antibody (acLys235) (ABIN8120743)

Target: Cortactin (CTTN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cortactin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Cortactin Antibody

Binding Specificity: acLys235

Purpose: Cortactin (Acetyl Lys235) Antibody

Specificity: Acetyl-Cortactin (K235) Polyclonal Antibody detects endogenous levels of Cortactin protein only when acetylation at K235.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized acetyl-peptide derived from the Internal region of human Cortactin around the acetylation site of K235.

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Cortactin

Target: Cortactin (CTTN)

Alternative Name: Cortactin

Background:

Synonyms: CTTN, EMS1, Src substrate cortactin, Amplaxin, Oncogene EMS1

Background: cortactin(CTTN) Homo sapiens This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010],

Gene Name: CTTN

Protein Name: Src substrate cortactin

Gene ID: 2017

UniProt: Q14247

Pathways: MAPK Signaling