Desmocollin 3 antibody

Catalog No. ABIN8120971

The Rabbit Polyclonal anti-Desmocollin 3 antibody (ABIN8120971) specifically detects Desmocollin 3 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Desmocollin 3 antibody (ABIN8120971)

Target: Desmocollin 3 (DSC3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Desmocollin 3 Antibody

Purpose: DSC3 Antibody

Specificity: DSC3 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Desmocollin 3

Target: Desmocollin 3 (DSC3)

Alternative Name: DSC3

Background:

Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014],

Gene Name: DSC3 CDHF3 DSC4

Protein Name: Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)

Gene ID: 1825

UniProt: Q14574