Dynamin 1-Like antibody (pSer616)

Catalog No. ABIN8121080

This Rabbit Polyclonal antibody specifically detects Dynamin 1-Like in WB. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for Dynamin 1-Like antibody (pSer616) (ABIN8121080)

Target: Dynamin 1-Like (DNM1L)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamin 1-Like antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Dynamin 1-Like Antibody

Binding Specificity: pSer616

Purpose: DRP1 (Phospho Ser616) Antibody

Specificity: Phospho-DRP1 (S616) Polyclonal Antibody detects endogenous levels of DRP1 protein only when phosphorylated at S616(human), S622(mouse), S635(rat)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human DRP1 (Ser616)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Alternative Name: DRP1

Background:

Synonyms: Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)

Background: This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013],

Gene Name: DNM1L DLP1 DRP1

Protein Name: DRP1 (Ser616)

Gene ID: 10059

UniProt: O00429