GIT2 antibody (pTyr592)

Catalog No. ABIN8121561

The Rabbit Polyclonal anti-GIT2 antibody is suitable to detect GIT2 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for GIT2 antibody (pTyr592) (ABIN8121561)

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIT2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GIT2 Antibody

Binding Specificity: pTyr592

Purpose: GIT2 (Phospho Tyr592) Antibody

Specificity: This antibody detects endogenous levels of Human GIT2 (phospho-Tyr592)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human GIT2 (Tyr592)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for GIT2

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Alternative Name: GIT2

Background:

Synonyms: ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)

Background: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G

Gene Name: GIT2 KIAA0148

Protein Name: GIT2 (Tyr592)

Gene ID: 9815

UniProt: Q14161

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling