Granulin antibody (AA 520-600)

Catalog No. ABIN8121807

The Rabbit Polyclonal anti-Granulin antibody is suitable to detect Granulin in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Granulin antibody (AA 520-600) (ABIN8121807)

Target: Granulin (GRN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Granulin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Granulin Antibody

Binding Specificity: AA 520-600

Purpose: Granulins Antibody

Specificity: This antibody detects endogenous levels of Human Granulins

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Granulins AA range: 520-600

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Granulin

Target: Granulin (GRN)

Alternative Name: Granulins

Background:

Synonyms: Granulins (Proepithelin, PEPI) [Cleaved into: Acrogranin, Paragranulin, Granulin-1 (Granulin G), Granulin-2 (Granulin F), Granulin-3 (Granulin B), Granulin-4 (Granulin A), Granulin-5 (Granulin C), Granulin-6 (Granulin D), Granulin-7 (Granulin E)]

Background: disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485], also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.,function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.,function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.,PTM:Granulins are disulfide bridged.,similarity:Belongs to the granulin family.,tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.,

Gene Name: GRN

Protein Name: Granulins

Gene ID: 2896

UniProt: P28799