IBTK antibody (AA 410-490)

Catalog No. ABIN8122183

The Rabbit Polyclonal anti-IBTK antibody (ABIN8122183) specifically detects IBTK in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for IBTK antibody (AA 410-490) (ABIN8122183)

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IBTK antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IBTK Antibody

Binding Specificity: AA 410-490

Purpose: IBTK Antibody

Specificity: IBTK Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 410-490

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for IBTK

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Alternative Name: IBTK

Background:

Background: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils.The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],

Gene Name: IBTK BTKI KIAA1417

Protein Name: Inhibitor of Bruton tyrosine kinase (IBtk)

Gene ID: 25998

UniProt: Q9P2D0