Leptin Receptor antibody (pTyr1141)

Catalog No. ABIN8122622

This Rabbit Polyclonal antibody specifically detects Leptin Receptor in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for Leptin Receptor antibody (pTyr1141) (ABIN8122622)

Target: Leptin Receptor (LEPR)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Leptin Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Leptin Receptor Antibody

Binding Specificity: pTyr1141

Purpose: Ob-R (phospho Tyr1141) Antibody

Specificity: Phospho-Ob-R (Y1141) Polyclonal Antibody detects endogenous levels of Ob-R protein only when phosphorylated at Y1141.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Ob-R (phospho Tyr1141)

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Leptin Receptor

Target: Leptin Receptor (LEPR)

Alternative Name: Ob-R

Background:

Synonyms: LEPR, DB, OBR, Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD antigen CD295

Background: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010],

Gene Name: LEPR OBR

Protein Name: Leptin receptor

Gene ID: 3953

UniProt: P48357

Pathways: JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour