LINGO1 antibody (AA 370-450)

Catalog No. ABIN8122624

The Rabbit Polyclonal anti-LINGO1 antibody (ABIN8122624) specifically detects LINGO1 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for LINGO1 antibody (AA 370-450) (ABIN8122624)

Target: LINGO1 (Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LINGO1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LINGO1 Antibody

Binding Specificity: AA 370-450

Purpose: LIGO1 Antibody

Specificity: LIGO1 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 370-450

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for LINGO1

Target: LINGO1 (Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1))

Alternative Name: LIGO1

Background:

Background: function:Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.,PTM:N-glycosylated. Contains predominantly high-mannose glycans.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 13 LRR (leucine-rich) repeats.,subunit:Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19.,tissue specificity:Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.,

Gene Name: LINGO1 LERN1 LRRN6A UNQ201/PRO227

Protein Name: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobilin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)

Gene ID: 84894

UniProt: Q96FE5