KDM3B antibody (AA 230-310)

Catalog No. ABIN8122715

This Rabbit Polyclonal antibody specifically detects KDM3B in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for KDM3B antibody (AA 230-310) (ABIN8122715)

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM3B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-KDM3B Antibody

Binding Specificity: AA 230-310

Purpose: KDM3B Antibody

Specificity: KDM3B Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 230-310

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for KDM3B

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Alternative Name: KDM3B

Background:

Background: cofactor:Binds 1 Fe(2+) ion per subunit.,domain:Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.,function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.,miscellaneous:Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene.,similarity:Belongs to the JHDM2 histone demethylase family.,similarity:Contains 1 JmjC domain.,tissue specificity:Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.,

Gene Name: KDM3B C5orf7 JHDM2B JMJD1B KIAA1082

Protein Name: Lysine-specific demethylase 3B (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA)

Gene ID: 51780

UniProt: Q7LBC6

Pathways: Warburg Effect