MAP2K5 antibody

Catalog No. ABIN8123012

This Rabbit Polyclonal antibody specifically detects MAP2K5 in WB, IHC and IF. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for MAP2K5 antibody (ABIN8123012)

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP2K5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MAP2K5 Antibody

Purpose: MEK-5 Antibody

Specificity: The antibody detects endogenous MEK-5 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Recombinant Protein of MEK-5

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 IHC 1:200-500. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, containing 0.5 % BSA, 0.02 % sodium azide as Preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Alternative Name: MEK-5

Background:

Synonyms: MAP2K5, MEK5, MKK5, PRKMK5, Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011],

Gene Name: MAP2K5

Protein Name: Dual specificity mitogen-activated protein kinase kinase 5

Gene ID: 5067

UniProt: Q13163

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway