MPRIP antibody

Catalog No. ABIN8123153

This Rabbit Polyclonal antibody specifically detects MPRIP in WB, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MPRIP antibody (ABIN8123153)

Target: MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPRIP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-MPRIP Antibody

Purpose: M-RIP Antibody

Specificity: M-RIP Polyclonal Antibody detects endogenous levels of M-RIP protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human M-RIP.

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MPRIP

Target: MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

Alternative Name: M-RIP

Background:

Synonyms: MPRIP, KIAA0864, MRIP, RHOIP3, Myosin phosphatase Rho-interacting protein, M-RIP, Rho-interacting protein 3, RIP3, p116Rip

Background: function:Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.,similarity:Contains 1 PH domain.,similarity:Contains 2 PH domains.,subcellular location:Colocalizes with F-actin.,subunit:Binds F-actin through its N-terminus (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.,

Gene Name: MPRIP

Protein Name: Myosin phosphatase Rho-interacting protein

Gene ID: 23164

UniProt: Q6WCQ1