MYST2 antibody (AA 100-200)

Catalog No. ABIN8123180

This Mouse Monoclonal antibody specifically detects MYST2 in WB, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for MYST2 antibody (AA 100-200) (ABIN8123180)

Target: MYST2 (MYST Histone Acetyltransferase 2 (MYST2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MYST2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: AB2413

Product Details anti-MYST2 Antibody

Binding Specificity: AA 100-200

Purpose: HBO1 mouse mAb

Specificity: This antibody detects endogenous levels of HBO1  protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 100 - 200 of the human HBO1 protein.

Isotype: IgG

Application Details

Application Notes: WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for MYST2

Target: MYST2 (MYST Histone Acetyltransferase 2 (MYST2))

Alternative Name: HBO1

Background:

Synonyms: KAT7,HBO1,HBOa,MYST2,Histone acetyltransferase KAT7,Histone acetyltransferase binding to ORC1,Lysine acetyltransferase 7,MOZ,YBF2/SAS3, SAS2 and TIP60 protein 2,MYST-2

Background: catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone. , domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. , domain:The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction. , function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. , PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. , similarity:Belongs to the MYST (SAS/MOZ) family. , similarity:Contains 1 C2HC-type zinc finger. , subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. , tissue specificity:Ubiquitously expressed, with highest levels in testis. ,

Gene Name: KAT7

Protein Name: HBO1

Gene ID: 11143

UniProt: O95251