NQO1 antibody

Catalog No. ABIN8123217

The Rabbit Monoclonal anti-NQO1 antibody is suitable to detect NQO1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC, IF and IP.

Quick Overview for NQO1 antibody (ABIN8123217)

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This NQO1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: AB1666

Product Details anti-NQO1 Antibody

Purpose: NQO1 Rabbit mAb

Specificity: This antibody detects endogenous levels of NQO1 protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogen: Recombinant protein (or fragment).

Isotype: IgG

Application Details

Application Notes: WB, 1:1000-1:5000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5 μg-4 μg antibody for 200 μg-400 μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for NQO1

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Alternative Name: NQO1

Background:

Synonyms: NQO1, DIA4, NMOR1, NAD (P) H dehydrogenase [quinone] 1, Azoreductase, DT-diaphorase, DTD, Menadione reductase, NAD (P) H:quinone oxidoreductase 1, Phylloquinone reductase, Quinone reductase 1, QR1

Background: This gene is a member of the NAD (P) H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein&apos, s enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD) , an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer&apos, s disease (AD) . Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Gene Name: >>Ubiquinone and other terpenoid-quinone biosynthesis, >>Metabolic pathways, >>Biosynthesis of cofactors, >>Pathways in cancer, >>Chemical carcinogenesis-reactive oxygen species, >>Hepatocellular carcinoma, >>Fluid shear stress and atherosclerosis

Protein Name: NQO1

Gene ID: 1728

UniProt: P15559