Nibrin antibody (pSer343)

Catalog No. ABIN8123328

The Rabbit Polyclonal anti-Nibrin antibody is suitable to detect Nibrin in samples from Human and Mouse. It has been validated for WB.

Quick Overview for Nibrin antibody (pSer343) (ABIN8123328)

Target: Nibrin (NBN)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nibrin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Nibrin Antibody

Binding Specificity: pSer343

Purpose: p95/NBS1 (Phospho Ser343) Antibody

Specificity: This antibody detects endogenous levels of Human Mouse p95 or NBS1 (phospho-Ser343)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human p95 (Ser343)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Nibrin

Target: Nibrin (NBN)

Alternative Name: p95/NBS1

Background:

Synonyms: Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)

Background: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008],

Gene Name: NBN NBS NBS1 P95

Protein Name: p95/NBS1 (Ser343)

Gene ID: 4683

UniProt: O60934

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response